Clinical and microbiological analysis of bloodstream infections caused by chryseobacterium meningosepticum in nonneonatal patients. Chryseobacterium meningosepticum is an aerobic gramnegative rod widely distributed in natural environments. Chryseobacterium flavobacterium meningosepticum a betalactam buster. Chryseobacterium meningosepticum and flavobacterium. Chryseobacterium meningosepticum as a cause of cellulitis and sepsis in an immunocompetent patient article pdf available in journal of medical microbiology 56pt 8. Elizabethkingia meningoseptica is a nonfermentative gramnegative bacillus that is ubiquitously found in hospital environments and as such, it has been associated with various nosocomial infections. A 11 year female child, from southasia of indian origin presented with fever, pain and swelling in right leg for 3 days with no significant past history. Chryseobacterium meningosepticum is a ubiquitous gramnegative bacillus historically associated primarily with meningitis in neonates and a wide variety of. Chryseobacterium meningosepticum is a lactosenonfermenting gramnegative bacilli ubiquitously found in the natural and hospital environment. Chryseobacterium is a genus of gramnegative bacteria.
Antimicrobial susceptibility and epidemiology of a. Formerly flavobacterium indologenes, chryserobacterium indologenes is a yellow pigmented, gramnegative filamentous, nonmotile rod and can be found in soil, plants, foodstuffs and water sources including those found in hospitals 1234. Host factors are the major determinants of the outcomes of c. Aug 02, 2019 flavobacterium meningosepticum from neonatal meningitis. All clinical isolates, which were initially misidentified as aeromonas salmonicida by an automated bacterial identification. Both organisms grow well and form colonies within 24. In vitro antibiotic synergy against flavobacterium meningosepticum.
Lin and colleagues describe 9 adults 4082 years of age and 2 children 0. Fifty isolates 24 chryseobacterium meningosepticum, 20 chryseobacterium indologenes, two chryseobacterium gleum, and 4 chryseobacterium spp. Chryseobacterium meningosepticum is a ubiquitous gramnegative bacillus historically associated primarily with meningitis in neonates and a wide variety of infections in immunocompromised patients. Chryseobacterium meningosepticum is rarely encountered as a pathogen causing peritonitis in adults. Elizabethkingia are opportunistic pathogens preferentially causing illness among neonates and, usually, immune compromised individuals with underlying medical conditions.
All neonates were colonized in the endotracheal tubes and respiratory secretions, but none of them. Chryseobacterium meningosepticum sepsis complicated with. Chryseobacterium meningosepticum infection and cardiac. Pdf elizabethkingia meningosepticum chryseobacterium. Chryseobacterium meningosepticum, formerly known as flavobacterium meningosepticum and cdc iia, is a gramnegative rod widely distributed in nature. During a period of eleven weeks two patients presented with septicaemia and. Elizabethkingia, chryseobacterium and myroides spp. We report two cases of sepsis in critically ill patients in two tertiary care hospitals in recifepe, brazil. Fifty isolates 24 chryseobacterium meningosepticum, 20 chryseobacterium indologenes, two chryseobacterium gleum, and 4. Endocarditis due to chryseobacterium meningosepticum bomb k. Chryseobacterium form typical yelloworange color colonies due to flexirubintype pigment.
With 215 c indologenes isolates between january 1, 2004 and september 30, 2011, at a medical center, we analyzed the relationship between the prevalence of c indologenes infections and total prescription of colistin and tigecycline, clinical manifestation, antibiotic susceptibility, and outcomes. Introduction we report the seventh case of chryseobacterium indologenes occurring in the united states of america. Sep 01, 2000 this is the first report of a cluster of atypically variant strains of c. Pdf a chryseobacterium meningosepticum outbreak observed. Chryseobacterium indologenes infection in a newborn. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Elizabethkingia meningoseptica formerly flavobacterium meningosepticum and, during 19942005 chryseobacterium meningosepticum is a gramnegative nonfermenting obligate aerobe. Chryseobacterium meningosepticum, formerly known as flavobacterium meningosepticum or cdciia, is a nonfermentative, nonmotile, oxidasepositive gramnegative rod that is widely distributed in nature. Pdf chryseobacterium meningosepticum as a cause of. An outbreak of nosocomial infections by flavobacterium meningosepticum in a neonatal intensive care unit is described. Bruun and ursing, 1987, in contrast members of all chryseobacterium species produce a yellow to orange nondiffusible flexirubin type pigment.
Ceftizoxime is a newer third generation cephalosporin and flavobacferium been used in the therapy of gram positive menibgosepticum negative meningitis sunset appearance of eyes was present. It is ubiquitously found in soil and water and it has also. Transfer of chryseobacterium meningosepticum and chryseobacterium miricola to elizabethkingia gen. Successful control of elizabethkingia meningoseptica outbreak. Chryseobacterium indologenes is an uncommon human pathogen. Chryseobacterium meningosepticum is a gramnegative rod with a worldwide distribution. Atypical chryseobacterium meningosepticum and meningitis. The genbankemblddbj accession numbers for the 16s rrna gene sequences of elizabethkingia meningoseptica atcc 253t and. We present the case of a patient with endstage renal disease who developed purulent pericarditis with c meningosepticum infection, which rapidly evolved into cardiac.
A chryseobacterium meningosepticum colonization outbreak in a. Chryseobacterium respiratory tract infections in patients. Chryseobacterium indologenes is an uncommon human pathogen reported in hospital outbreaks in taiwan and there have been some sporadic cases reported in europe and in the usa mainly from immunesuppressed patients. Pdf chryseobacterium meningosepticum bacteremia in diabetic. Jun 22, 2015 in this report we have presented a patient with extreme malnutrition and a hepatic lesion. Alternatively, you can download the file locally and open with any standalone pdf reader. Some species of chryseobacterium have been involved in human infections, acting as sporadic but severe opportunistic nosocomial pathogens.
A 54yearold woman who underwent continuous ambulatory peritoneal dialysis for 8 years developed peritonitis due to c. Phylogenetic insights into the diversity of chryseobacterium. Elizabethkingia meningoseptica is a gramnegative, rodshaped bacterium widely distributed in nature e. In the hospital environment, they exist in water systems and wet surfaces. We report a rare case of urinary tract infection by chryseobacterium indologenes in a young girl, operated for renal calculus and successfully treated with piperacillintazobactam combination. Pdf the chryseobacterium species are inhabitants of soil and water.
Chryseobacterium meningosepticum is a ubiquitous gramnegative bacillus historically associated with meningitis in premature neonates. The pathogen causes meningitis in premature and newborn infants and pneumonia, endocarditis, postoperative bacteremia, and meningitis usually associated with severe underlying illness in adults 47. This report documents a rare case of chryseobacterium indologenes urinary tract infection in senegal. Most infections have been detected in hospitalized patients with severe underlying diseases who had indwelling devices implanted.
A chryseobacterium meningosepticum colonization outbreak in a neonatal intensive care unit. Chryseobacterium meningosepticum bloodstream infections in 11 nonneonatal patients were reported. Chryseobacterium flavobacterium meningosepticum, an organism resistant to multiple antibiotics, is an occassional cause of infection in immunocompromised adults and in neonates, in whom it most commonly causes meningitis. Chryseobacterium meningosepticum journal of clinical microbiology. Unforeseeable presentation of chryseobacterium indologenes. Chryseobacterium species are chemoorganotrophic, rod shape gramnegative bacteria. Endocarditis due to chryseobacterium meningosepticum k bomb, a arora, n trehan abstract chryseobacterium meningosepticum is a gram negative rod widely distributed in nature. The pathogen causes meningitis in premature and newborn infants and pneumonia, endocarditis, postoperative bacteremia, and meningitis usually associated with severe underlying illness in. We present a case of ventilatorassociated pneumonia caused by c. Chryseobacterium meningosepticum bacteremia in diabetic. Pdf bacteremia due to elizabethkingia meningoseptica. The crystal structure of the classb betalactamase, blab, from the pathogenic bacterium, chryseobacterium meningosepticum, in complex with the inhibitor, dcaptopril, has been solved at 1.
In summary, cefepime was more active than cefpirome against the c. At the time of writing january 2019, the list of prokaryotic names with standing in nomenclature. Chrysobacterium meningosepticum 20041001 ahc media. Lower respiratory tract 52% and blood 46% were the major sites. Waterborne elizabethkingia meningoseptica in adult critical. Susceptibilities of chryseobacterium indologenes and. Chryseobacterium meningosepticum is the most pathogenic member of the genus. Chryseobacterium indologenes an overview sciencedirect. Oct 01, 2004 host factors are the major determinants of the outcomes of c. Apr 24, 2020 this is the first report of a cluster of atypically variant strains of c meningosepticum, which may be an emerging pathogen in newborns and the immunocompromised. Flavobacterium meningosepticum, cdc group iia bacteriology a bacterium of soil, water, plants, foods, hospital waterincubators, tap water, hemodialysis systems, pharmaceuticals mode of transmission uncertain, but probably linked to contaminated medical devices and fluids. Elizabethkingia meningoseptica, previously known as chryseobacterium meningosepticum, is a gramnegative bacillus that is widely distributed in nature. Implications for therapeutic options clinical infectious diseases, may 1998 m.
They can be found in freshwater, saltwater, and soil 106, 110, 119. A limited range of antibiotic classes are available for treatment of chryseobacterium meningosepticum infections. Chryseobacterium infection may present with a variety. Clinical and epidemiological features of chryseobacterium. Neonatal infections often occur as outbreaks with environmental contamination being the source. Chryseobacterium and elizabethkingia species may be long, thin, slightly curved, and occasionally filamentous on gram stain. Elizabethkingia, chryseobacterium and myroides species.
Bacteremia due to elizabethkingia meningoseptica sciencedirect. The patient received vancomycin therapy for 21 days and was discharged in a state of complete recovery. Limited data are available on chryseobacterium spp. Chryseobacterium flavobacterium meningosepticum a beta. Yellowpigmented, gramnegative organisms isolated from raw chicken were investigated by means of a polyphasic taxonomic approach and were shown to represent a novel species in the genus chryseobacterium, for which the name chryseobacterium vrystaatense sp.
Chryseobacterium gleum infection in patient with extreme. Flavobacterium meningosepticum from neonatal meningitis. This course will focus on one species of elizabethkingia, namely elizabethkingia meningosepticum. Most frequently associated with neonatal meningitis 3,4, the organism also has been described in. The genus contains more than 100 described species from diverse habitats, including freshwater sources, soil, marine. Atypical chryseobacterium meningosepticum and meningitis and. Apr 12, 2016 we report for the first time a case of community acquired chryseobacterium indologenes soft tissue infection in an immunocompetent patient. Clinical infection caused by c meningosepticum is very rare among healthy adults. Aug 16, 2009 to report the epidemiologic, bacteriologic, and clinical features of a chryseobacterium meningosepticum outbreak in a neonatal intensive care unit nicu of a referral teaching hospital. As an agent of neonatal meningitis, it reportedly demonstrates mortality rates of up to 57% and produces severe postinfection sequelae including hydrocephalus, deafness, and developmental delay. Both cefepime and cefpirome had poor activity against c. Elizabethkingia species were first described by elizabeth o.
Elizabethkingia meningoseptica, previously known as chryseobacterium meningosepticum, is widely distributed in soil and water including municipal water. The taxonomic positions of six strains including the type strain of chryseobacterium meningosepticum king 1959 vandamme et al. Jan 14, 2011 chryseobacterium indologenes is an uncommon human pathogen. The chryseobacterium species are inhabitants of soil and water.
Identification and epidemiological relatedness of clinical. A chryseobacterium meningosepticum colonization outbreak. In vitro antibiotic synergy against flavobacterium. Although she received intravenous antibiotics with good in vitro activity against the organism, the. The progressive improvement in laboratory studies is shown in table. We report on the case history of a 17yearold boy with thalassemia major and meningitis and sepsis caused by c. First isolation and characterization of chryseobacterium. Elizabethkingia meningosepticum nursing ceu ceufast. Elizabethkingia meningoseptica strains either are not pigmented or produce a weak yellow nondiffusible pigment e. Elizabethkingia meningosepticum chryseobacterium meningosepticum infections in children article pdf available in international journal of pediatrics 201. Patients and methods from april to october 2002, a strain. Urinary tract infection by chryseobacterium indologenes. Elizabethkingia meningoseptica, previously known as chryseobacterium meningosepticum, 1 is widely distributed in soil and water including municipal water supplies with chlorination.
Of these species, chryseobacterium meningosepticum is the most. Waterborne elizabethkingia meningoseptica in adult. This is the first report of a cluster of atypically variant strains of c meningosepticum, which may be an emerging pathogen in newborns and the immunocompromised. Patients and methods from april to october 2002, a strain of c. Kwang kyu kim 1, myung kyum kim 1, ju hyoung lim 1, hye yoon park 1, sungtaik lee 1. Sentry program during the 5year period 1997 to 2001 revealed that chryseobacterium species constitute only 0. A chryseobacterium meningosepticum outbreak observed in 3 clusters involving both neonatal and nonneonatal pediatric patients. We present the case of a patient with endstage renal disease who developed purulent pericarditis with c.
Pdf chryseobacterium meningosepticum is a ubiquitous. Unlike many bacteria, it produces a phosphateirrepressible periplasmic alkaline phosphatase ap. Most frequently associated with neonatal meningitis 3,4, the organism also has been described in osteomyelitis. Although there were a mere 18 species of chryseobacterium in 2006 5, that number had risen to 58 by 2014 6. From 1996 to 1999, 17 culturedocumented systemic infections due to novel, atypical strains of chryseobacterium meningosepticum occurred in two newborns and 15 immunocompromised patients in a medical center in taiwan. Chryseobacterium respiratory tract infections in patients with cystic fibrosis. Chryseobacterium meningosepticum as a cause of cellulitis. In the hospital she was provided with the intravascular catheter, urinary catheter and endotracheal tubus and was on mechanical ventilation for 18 days.
Nevertheless the knowledge of the diversity of species associated with fish disease is partial due to the problems for a correct identification at the species level based exclusively on phenotypic laboratory methods. Chryseobacterium meningosepticum is a rare pathogen in cases of bacterial meningitis in adults and adolescents. In the hospital environment, they exist in water systems and wet. There have been an increasing number of infections in fish associated with different species of chryseobacterium, being considered potentially emerging pathogens. For reasons that are explained in the section phylogeny, the splitting of the genus chryseobacterium was proposed very recently kim et al. He was successfully treated with vancomycin and ceftazidime for three weeks with good clinical outcome. Elizabethkingia meningoseptica international journal of infection. Chryseobacterium indologenes and chryseobacterium gleum are human pathogens and are former members of the genus flavobacterium vandamme et al. A case of healthcare associated pneumonia caused by. Chryseobacterium indologenes in a woman with acute. If you do not see its contents the file may be temporarily unavailable at the journal website or you do not have a pdf plugin installed and enabled in your browser. King at the communicable disease center now the centers for disease control and prevention in 1959. Chryseobacterium meningosepticum and chryseobacterium.
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